To eradicate these molecules in the course of selection, we first characterized them and then modified the selection scheme accordingly so as to reduce their chances of survival.
1% the size of most clinically detectable, internal cancers will typically be impossible to eradicate by single molecule chemoprevention when resistance is possible.
For example, a small molecule inhibitor of Shh succeeded in eradicating spontaneous medulloblastoma in transgenic and transplantation mouse models [ 5].
The brucellae, and probably other pathogenic α-Proteobacteria have developed furtive characteristics by eradicating, modifying or hiding otherwise moderately active PAMP-bearing molecules, to the point that practically not recognized by the corresponding receptors.
Our results suggest that curcumin acted both-ways during protection of Hp-infection by eradicating Hp as well as potentially targeting the key molecules (MMP-3 and -9) involved in the Hp-induced gastric diseases.
One way to overcome this is arming of the virus with an immunostimulatory molecule; an immune response against the tumor would help in eradicating non-infected malignant cells both locally and also at metastatic sites.
Consequently, several therapeutic strategies, such as monoclonal antibodies and small molecule inhibitors, have been employed to target these pathways and succeeded in eradicating spontaneous medulloblastoma in transgenic and transplantation mouse models [ 5].
Eradicating it is quite another.
It's not exactly eradicating malaria.
