In all cases, the dosage was converted to the equivalent rat dose of rats based on the human clinical dose [ 12].
This approach could also be applied, with the equivalent rat or mouse gene arrays, to the investigation of responses to toxicants in rodent models.
In fact comparing the human and rat sequences reveals that the first 26 amino acids of the equivalent rat sequence is actually the Iγ_i3-specific insert (Ref. [5], see Fig. 1C).
This process is likely driven by increases in thalamo-cortical and cortico-cortical connectivity through the transient subplate zone, as its ablation in preterm-equivalent rats eliminates both endogenous and evoked spindle burst activity, and permanently alters barrel cortex histological patterning (Kostovic and Rakic 1990; Kostovic and Jovanov-Milosevic 2006; Tolner et al. 2012).
In lieu of mouse calcitonin standards, values were expressed as pg-equivalents rat calcitonin/ml; the stated detection limit of the assay was 1.0 pg/ml.
Groups were constituted in order to exhibit equivalent rates of rats with small, moderate and large MI.
Small-animal SPECT and PET systems are often modified versions of their clinical equivalent, where rats and mice form the majority of the experimental animal population.
The hypoxic group was placed in a hypobaric chamber, where the ambient pressure was continuously held at 500 mbar which was equivalent to rats breathing 10% oxygen at standard pressure.
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In support of a possible role for Wnt5a in axon stalling, we found that Wnt5a had a negative effect on DA neurite length in vitro, at E14.5 (approximately equivalent to rat E16.5) (Fig. 3), and that axonal innervation of the dorsolateral striatum was accelerated in the Wnt5a−/− mice.
For comparison, human 27 30 GW is roughly equivalent to rat P1 P2 when comparing neurogenesis and axon extension events (translatingtime.net).net
