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We note that organisms with similar lifestyles across a wide phylogenetic range tend to conserve equivalent interactions and network motifs.
The genetic efficiency seen in viruses is manifested in their self-assembling nature, as multiple copies of a few proteins, making repeated equivalent interactions, assemble into symmetric closed shells encapsidating their own genome.
However, equivalent interactions are not observed in the three GPCR crystallized in their active conformation, whereas four of the 18 GPCR inactive experimental structures used in this study (16 structures used as templates plus 2 structures not used as templates due to low amino acid sequence identity) show weak contacts between residues at positions 3.30 and 4.58.
This model suggested the likelihood that equivalent interactions stabilize the transition state in YqeH (Fig. 4a) and MnmE.
knowledge of equivalent interactions between orthologs (interologs) in alternative species [ 42, 43]; iv.
Hydrogen bonds mediated by W5 were replaced by equivalent interactions of the O2S oxygen atom of the sulphonic acid moiety in the PMSF molecule.
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Based upon the proposed theory, a construct strategy was developed for designing the ETC by altering the equivalent interaction angle with the direction of heat flow: relatively small average interaction angle for thermal conduction and relatively large one for thermal insulation.
In the bovine and Drosophila enzymes the equivalent interaction is achieved via the main-chain carbonyl group of R876 (Drosophila numbering) with O2 (dist ∼2.7 Å).
An equivalent interaction between CF IIm and CstF in mammalian cells has not been demonstrated.
interaction supported by presence of an equivalent interaction between a pair of orthologs (interolog) in another of these four species [ 42, 43]; iv.
However, we note that AAAPAA (and not AAPAAA) would bind favorably with an (almost) equivalent interaction had we considered the other edge as the binding site.
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