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Exact(2)
A likely explanation is that the indirect interaction of the 1-phosphate of IP3 with the backbone of K569 (Bosanac et al., 2002) is stronger than the equivalent interaction with the 2′-phosphate of AdA.
To summarize, the same loop at the N-terminus of the LARA domain appears involved in (1) positioning the foot in respect to the rest of the leg so that to allow for equivalent interaction with both the inner and the outer LdcI rings, (2) binding to LdcI, and (3) binding to the triple helical bundle of the adjacent RavA.
Similar(55)
The structure for loop 6 in TIM from eukaryotes and bacteria is similar to that for archeal TIM, because the equivalent N-terminal hinge residue (W168 or E147) is stabilized by functionally equivalent interactions with the protein core.
Based upon the proposed theory, a construct strategy was developed for designing the ETC by altering the equivalent interaction angle with the direction of heat flow: relatively small average interaction angle for thermal conduction and relatively large one for thermal insulation.
However, we note that AAAPAA (and not AAPAAA) would bind favorably with an (almost) equivalent interaction had we considered the other edge as the binding site.
In the bovine and Drosophila enzymes the equivalent interaction is achieved via the main-chain carbonyl group of R876 (Drosophila numbering) with O2 (dist ∼2.7 Å).
The guanidino group made the equivalent crucial interaction with Asp189 in the S1 pocket and, additionally, formed hydrogen bonds with Ser190 and Trp215.
We note that organisms with similar lifestyles across a wide phylogenetic range tend to conserve equivalent interactions and network motifs.
In addition, while van der Waals energies of Cpd30-12 wequivalentlent for its interaction with the Stat3 SH2 domain and the Stat1 SH2 domain, the 5 selective compounds were much more favorable for their interaction with the Stat3 SH2 domain than with the Stat1 SH2 domain (Figure 3I).
Two observations, however, suggest that the interaction of CTR1 with subfamily 1 receptors is not necessarily equivalent to its interaction with subfamily 2 receptors.
Wolf and Hager's (2006, 2009) maternal offspring coadaptation theory supposes that the two alleles in an offspring code for non-equivalent fitness interactions with the mother, favoring imprinted expression.
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