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For the two cases in this review where equivalence designs were apparently employed [ 20, 39] there was either a lack of precision in the aim of the trial, or an inappropriate analysis.
Similar(59)
The certainty equivalence design is kept throughout the iterations when the model parameters is updated.
The Cordis Randomized Iliac Stent Project US (CRISP-US) trial evaluated, with an equivalence design, the performance of the shape memory alloy recoverable technology (SMART) nitinol self-expanding stent and the stainless steel Wallstent for treating iliac artery disease after suboptimal percutaneous transluminal angioplasty (PTA).
Admittedly the odd reporting in this case had much to do with the investigators' choice of an equivalence design, and with the very tempered language the investigators themselves used in their paper.
Although the trial did not have an equivalence design, all subjects who started therapy followed the protocol schedule and there was no rescue therapy.
The study is a pragmatic, multicentre, RCT of equivalence design.
No interim analysis was performed because of the equivalence design of the trial.
Furthermore, in an equivalence design non-compliance will provide an underestimation of the effect, making it more plausible that there truly is no equivalence between both interventions.
We used a within-subjects equivalence design, in which all participants completed both versions of the RMDQ on the same day.
It would have been clearer to refrain from the term 'similar' in this respect and stick to the terminology that fits the equivalence design of the study.
This is a pragmatic, multicentre, randomised controlled trial (RCT) of equivalence design comparing AS replacement at 4 (control) versus 7 (experimental) days.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com