Exact(24)
He has a core, and was able to maintain his equipoise, for example, even as his campaign stagnated through the summer and fall.
The trial is notable for its use of a structurally equivalent comparison treatment, called Personal Readjustment and Education (PRE), which was created for the study and is intended to maximize equipoise for both participants and treaters.
The feasibility of such a trial was examined in terms of whether there was "equipoise" for a majority of likely investigators in the field around the trial question, what other issues might impact accrual to the trial, and how many patients would be required to answer which of these two treatment arms was better.
Their equipoise requirement also rises dramatically, from near equipoise for the 40s (0.4%) to 21.5% for the 60s.
This study may provide equipoise for an interventional study of echocardiographic versus CVP-driven volume expansion among patients with early severe sepsis or septic shock.
Table 2 Percentage increase in gap between relative Loss of Lifetime performance ratings for PSA and No PSA screening options needed to produce equipoise for each 4 cluster solution Cluster LCA PAM Ward's Equals 19 25 39 Very High Lifers 1 1 1 Moderate Lifers 3 6 8 Very High Sexers … 56 43 Moderate Biopsers 95 … ….
Similar(36)
Additionally, the SEND trial presented more problems for equipoise and for patient-reported aversion to recruitment, perhaps confirming the interdependence of these two issues discussed above.
However, as the available comparative effectiveness data clearly suggest that SABR results in comparable outcomes to surgery [ 19, 50], and as guidelines [ 18] have taken this into account, more effort should be undertaken to increase awareness of this equipoise of options, for example during professional training of clinicians.
11 There is as yet no sense of a level playing field for evaluation, so the criterion of equipoise, required for a randomised trial, is not attained.
Ethics and equipoise: rationale for a placebo-controlled study design of platelet glycoprotein IIb/IIIa inhibition in coronary intervention.
Critics respond that even when clinical equipoise obtains for the population of patients, the specific circumstances of individual patients within that population may imply that one of the treatments under investigation is better for them (Gifford 2007).
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