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The equilibrium is difficult, according to many.
In contrast, during the retrograde stage, both the decrease in temperature and the presence of (hbox {H}_2hbox {O} -undersaturated cO} -undersaturatedlly hinder the progress of rehydration reaconditionsd thus, equilibrium is difficult to achieve (Stüwe 1997).
The existence of equilibrium is difficult to fully demonstrate in models such as these due to potential kinks in demand which can prevent profit functions from being globally concave.
At this stage deciding what causes this shift in the final equilibrium is difficult, however this result should not be considered unexpected, especially in light of similar changes in electron distribution observed in antimycin-inhibited cytochrome bc1 when a barrier for a particular electron transfer reaction was specifically modified [20].
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And the equilibrium is hard to find.
Several versions of the UNIFAC model are frequently used for process design when experimental determination of phase equilibrium data is difficult or time-consuming.
Hence, it requires longer equilibrium time and is difficult to control.
A quantitative study of the physical properties of model membranes out of equilibrium is extremely difficult.
The preparation of aqueous solutions of monomer lipophilic ligands in equilibrium with protein bound ligand is difficult.
The initial stage close to the nozzle exit is furthest from thermodynamic equilibrium and the information of droplets is difficult to obtain by experimental ways due to the high density of droplets.
Moreover, since equilibrium constants in the NIST-TECR database are measured in a variety of pH and ionic strength levels, it is difficult to extrapolate the equilibrium constant for the conditions prevailing in an organism or system of interest.
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