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Adopting the mean value of Uniaxial Compressive Strength for intact rock (UCSi) of 78.2 MPa, unit weight of 26 kN/m3, RMR value of 30 and intact rock constant mi equal to 8, a limit equilibrium analysis was performed in order to estimate the stability for the derived profile (Fig. 8).
Sedimentation equilibrium analysis was performed at 20°C at 10,000, 12,000 and 14,000 rpm using a Beckman Optima XL-A analytical ultracentrifuge equipped with a 60Ti rotor and six channel centerpieces.
Due to the extreme low counts for the TT allele, Hardy-Weinberg equilibrium analysis was performed to exclude the possibility of experimental artefacts misleading the results.
Hardy-Weinberg equilibrium analysis was performed by comparing the detected genotype distribution with the theoretical distribution estimated on the basis of the allele frequencies.
Sedimentation equilibrium analysis was performed at 20 °C in a Beckman XL-I analytical ultracentrifuge, following a standard operating procedure SE_IO_07.1 at sample concentrations of 7.0 and 0.5 mg·ml−1 (547 and 39 μM respectively).
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and Prism GraphPad version 5. Steady state analysis was performed based on the equilibrium response.
The heat energy transport analysis was performed under the thermodynamic equilibrium condition with phase-summed effective thermal properties.
Sensitivity analysis was performed by excluding the Hardy-Weinberg equilibrium (HWE -violating studies [ 25].
A coupled neutronics and thermal hydraulics analysis was performed for the proposed inverted pressure tube type (IPTT SCWRR and an equilibrium core was analyzed.
Analysis was performed in the UK subset of samples using best-guess genotypes from variants passing the QC thresholds: information score ≥0.9, MAF ≥0.01 and significant deviation from Hardy Weinberg equilibrium in controls >1.0 × 10−3.
Analysis was performed from March to July 2018.
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