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aPooled analysis was performed by including the results of single marker (either the most specific or the most sensitive in cases with equal specificity) in cases where multiple markers were assessed per study.
aPooled analysis performed by including results of single marker (either the most specific or the most sensitive in cases with equal specificity) in cases where multiple markers were assessed per study.
Robustness of the model was further confirmed by sensitivity analysis using pooled data from a single marker for each study (either the most specific or the most sensitive in cases with equal specificity) revealing an overall OR 7.10 (95%CI, 4.21-11.98; I2 = 0; Figure 3B).
Prospective analysis of 46 consecutive clinical samples submitted for AdV testing showed greater sensitivity and equal specificity of the AdV PCR than viral culture.
While the rapid strep test is quicker, it has a lower sensitivity (70%) and statistically equal specificity (98%) as throat culture.
However, no comparison was made at an equal specificity.
Similar(42)
To evaluate to what extent an increase in sensitivity by double FIT sampling went at the cost of decreased specificity, single FIT and the three double FIT strategies were analyzed at equal specificities.
The Q* point is the intersection between a symmetrical SROC curve and the antidiagonal line, at which sensitivity equals specificity.
Main outcome measures were: sensitivity, specificity, positive and negative likelihood ratios of the primary studies, weighted means of these parameters in each comparison (clinical examination, radiography, and ultrasound compared to a reference standard in diagnosing AMS), and summary ROC curves and their Q* points where sensitivity equals specificity.
Q* values, defined by the point where sensitivity equals specificity, were calculated from the SROC curves.
The optimal cutoff value was chosen as the q value of the ROC curve, at which sensitivity equals specificity.
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