Exact(1)
It can, thus, be summarized that the assignment of probable functions to novel proteins involved in aromatic degradation simply based on similarity using best hits leads to functional misannotations as phylogenetically different enzymes may show equal similarities to the query enzyme.
Similar(59)
In this case, the innocent suspect and fillers are of equal similarity, which should result in the greatest amount of siphoning (protection for the innocent suspect).
The other way around however, number of similar positions (similarity) is not always an indication of relatedness [41]: species with equal similarity scores might still be different at specific positions.
CcLG04 showed almost equal similarity to MtChr04 (21) and MtChr05 (18).
However, this read has equal similarity to the paralogous site in NANOGP9 and thus cannot be conclusively assigned to NANOGP8.
The three control groups clustered under one node, whereas the chemical treatment groups formed a separate node of compound-independent clusters, indicating equal similarity within and between the transcriptional responses induced by the three estrogens.
The former shows roughly equal similarity to members of both the Sp and KLF subfamilies, while the latter appears to be a highly diverged and relatively unique member of the Sp/KLF family.
This cautions against assumptions that orthology equals similarity in cellular responses.
Specifically, we ask whether the algorithm is able to decide between two vertices in G′ with equal vertex similarity to i in G, one of which has also interaction similarity with i (the true ortholog) and the other shares no interactions (the spurious ortholog).
The two Physcomitrella SPA proteins, SPAa and SPAb are highly similar to each other (89% amino acid sequence identity) and both share equal sequence similarity to the Arabidopsis SPA1.
Two further bands were identified as Helicobacter although equal sequence similarity was attributed to multiple species.
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