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The study detailed here is the first to compare these two related SERMs in a mouse mammary premalignant transplant model and shows that ospemifene has equal effects to tamoxifen in mammary lesions.
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Second, we were underpowered in the Hispanics, with only 55% power to observe a significant effect (P<0.05) at rs16847548, assuming equal effect to that observed in non-Hispanic Whites.
However, xenografts arising from 4T1.2 mammary adenocarcinoma cells overexpressing the protease-resistant IGFBP-4 grew significantly slower than 4T1.2 xenografts expressing WT IGFBP-4 or the empty vector (Ryan et al, 2009), which is in contrast to our PR variant that had an equal effect to the WT IGFBP-2.
Further, in an earlier study a dose-response curve was performed, and this dosage had an equal effect compared to 20 mU/min in regard to stimulating colonic peristalsis [ 5].
However, the Pilates method showed an equal effect compared to other forms of exercise and massage therapy, although these results are still conflicting.
This means that these variables are assumed to have equal effects across the categories of self-assessed health and hence across the four binary models.
Histone deacetylase inhibitors (HDACIs) tend to show equal effects on gene activation and repression [ 2- 4].
The other haplotypes do not appear to have equal effects on response.
Below are three assumptions that correspond to assuming equal effects using three different methods of reporting treatment effects.
Based on the SAFE trial, albumin and crystalloids appear to have equal effects on mortality in critically ill patients, with the exception of patients with traumatic brain injury.
Second, liquid phase kinetics predicts that mismatches anywhere in the oligo (other than in the last 3 bases) ought to have equal effects on binding [ 19, 21- 25].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com