The properties of the Fe-S centers have been studied primarily by EPR spectroscopy [6], [7], [8], [9], [10].
Video recordings were obtained at three points during the observation period of 13 months: 1 month prior to deployment of the EPR, 4 months after deployment of the EPR, and 1 year after deployment of the EPR.
The long lifetime of the 4A2 excited state allows for detection by EPR measurement25.
These systems are capable of specifically targeting tumoral tissues because of their size, which permits to exploit the enhanced penetration and retention (EPR) effect4.
Owing to the ~12 nm hydrodynamic size and long blood circulation (half-life time of ~16 h, see next section), p-FE is expected to exhibit high tumor accumulation through the EPR effect25, 29, 30.
The compounds have been comprehensively characterized by elemental analysis, spectroscopic methods (IR, UV Vis, EPR, 1H and 13C NMR spectroscopy), ESI mass spectrometry and magnetic susceptibility measurements.
Bioactivation of AfB1 occurs in hepatocytes and are effected by the system of cytochrome P450, localized on membranes of the smooth EPR [1, 21, 22].
(b) Edge image of left EPR: 6.18.
Meanwhile, the other one remains active to EPR [35].
This phenomenon is known as 'enhanced permeation and retention' (EPR) [58, 60].
This behavior is called an enhanced permeation and retention (EPR) effect[7, 8, 9].
