Sentence examples for epo molecule from inspiring English sources
Each EPO molecule has two EPO receptor (EPOR) binding sites.
He walked in to turn the light off, only to discover scientist Fu-Kuen Lin still working on finding the EPO molecule.
The separation of haematopoietic and neuroprotective properties upon slight modification of the EPO molecule ultimately proved the haematopoiesis-independent effect of EPO on the nervous system [ 6].
EpoR is activated when a single Epo molecule binds two cell-surface EpoR molecules and effectively "cross-links" them (Fig. 1b) [ 39– 42].
Binding of a single EPO molecule to two adjacent EPO receptors on the membrane of target cells leads to homodimerization of the receptors and the triggering of different intracellular signaling pathways that might play an as yet unidentified role in cellular protection from stress.
The stepwise accumulation of substitutions onto the Epo molecule was continued onwards from pMRK417 to pMRK431, where all 31 residues that differ between Epo and Pla and that are located on the extracellular side of the outer membrane on the protein have been substituted towards Pla.
To overcome this concern, whole molecule EPO administration would have to be limited to very short term use.
Several molecules associated with the astrocyte/microvascular interface are also altered, in particular increases in EPO-r (EPO receptor), the MDR1 (multidrug resistance gene-1) encoded P-glycoprotein (Tishler et al., 1995), CD44 and plectin 1 (Lee et al., 2007), among others (de Lanerolle et al., 2010).
RHu-EPO was not capable of activating JAK-2, STAT-3 and STAT-5, i.e. decisive components of EPO-mediated signal transduction, or of inducing Bcl-2, a well-known effector molecule of EPO-mediated protection.
Studies using this antibody have indicated that many tumour cell lines express low-to-undetectable levels of EpoR and that any EpoR present is not functional (exposure of the cell lines to Epo does not activate signalling molecules such as STAT5 that function downstream of EpoR) (Swift et al, 2010).
While these molecules are attractive alternatives to EPO with the potential for less side effects these endothelial and pressor effects may actually be beneficial in sepsis syndromes.
