The platelet size is also connected with its life time – small platelets are regarded as older, having undergone many episodes of activation whereas large platelets are considered younger and more active [ 24].
Repeated episodes of activation of the trigeminovascular system can sensitize central pain pathways and lead to migraine chronicization [18].
However, it has been hypothesized that the release of neuropeptides induces vasodilation in meningeal areas and neurogenic inflammation so that repeated episodes of activation of the trigemino-vascular system can sensitize central pain pathways and lead to migraine chronicization [10].
Episodes of activation were related to the periods of routine nursing handover (07:00, 13:00 and 21 00), routine nursing observations (02 00, 06:00, 10 00, 14 00, 18 00 and 22 00), and commencement and completion of the daily medical shift (08 00 18 00).
These observations suggest that a single episode of transcriptional activation is, therefore, sufficient to induce heritable transgene silencing in a specific subset of lines that persists for at least several cell cycles.
However, in this study we show that after one episode of transcription activation, the transgene is transcriptionally silenced in a subset of lines associated with tail-to-tail inverted repeats.
This sequence of activation is much faster than that occurring at the onset of a spontaneous episode presumably because the afferent stimulus provides a synchronized transient.
Striatal neuronal activity was recorded, first, during cortical slow-wave activity (SWA) which accompanies deep anaesthesia and is similar to the activity observed during natural sleep, and during episodes of cortical activation which contain patterns of activity that are more analogous to those observed during the awake, behaving state (Steriade 2000).
To study the dynamics of spontaneous CA ignition we identified all episodes of CA activation that occurred during the period of spontaneous network activity recorded.
