Sentence examples for epigenetic modifying from inspiring English sources
The aberrant epigenetic patterns can be corrected by treatments with "epigenetic modifiers" or "epigenetic modifying agents" [ 77] that are in clinical trials of various phases [ 76].
Although some may function as individual enzymes, most epigenetic modifying proteins work as members of higher order protein complexes which often contain several epigenetic modifying enzymes, collectively controlling multiple distinct epigenetic marks.
We discuss its importance to human development, genomic stability, gene expression, epigenetic modifying agents as well as briefly introduce the expansive field of cancer epigenetics.
Zucconi, B. E. & Cole, P. A. Allosteric regulation of epigenetic modifying enzymes.
Epigenetic modifying enzymes have been proven to play significant roles in gene regulation and cancer pathogenesis.
During her years at the NCI, Dr. Bates led a highly successful translational research program focused on mechanisms of multidrug resistance and approaches to evaluate and improve the activity of epigenetic modifying agents.
Only genes with Δ values above 5 were considered as differentially epigenetic modified genes.
In addition, mutations and genetic alterations of epigenetic-modifying enzymes frequently have been reported in these myeloid malignancies, emphasizing the importance of epigenetic deregulation in the initiation, progression, and outcome of these disorders.
They were found to be regulated by decreases in the epigenetic-modifying enzymes HDAC1 and DNMT1 as well as survivin in colon cancer cells [ 75].
Azacitidine and panobinostat showed a trend to improving global health status and patient-reported fatigue in clinical responders after six cycles, suggesting potential for QoL benefits in patients receiving this epigenetic-modifying regimen.
At the same time, the highly tractable epigenetic-modifying enzymes that are critical for pathogenesis and treatment response will likely present potential targets for the next wave of targeted therapies.
