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We find transcriptional and epigenetic alterations within altered replication timing regions between normal and cancer cells.
Each of these epigenetic alterations serves to regulate gene expression without altering the underlying DNA sequence.
Such epigenetic alterations contribute to gliomagenesis.
Gene Ontology analysis of epigenetic alterations in NGPS-fibroblasts.
However, TGCTs harbour epigenetic alterations, which can be targeted by specific therapeutic approaches.
Zouridis, H. et al. Methylation subtypes and large-scale epigenetic alterations in gastric cancer.
Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation.
Equally important is emerging data demonstrating that environmental exposures contribute to epigenetic alterations.
Sadri-Vakili G. Cocaine triggers epigenetic alterations in the corticostriatal circuit.
Unlike genetic mutations, epigenetic alterations are often reversible and are promising drug targets.
Epigenetic alterations in tumors also include histone modifications and H19-induced SAHH activity changes which itself could alter histone modification.
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