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Alternatively, a genetic predisposition or an epigenetic alteration [ 24, 25] may prompt susceptibility to multiple infections.
(2) Development of reservoir spaces during the epigenetic alteration stage.
Epigenetic alteration is another important mechanism for oncogenesis.
Epigenetic alteration is the alteration of epigenomes (surrounding histone proteins) without changing the DNA sequence.
Epigenetic alteration in carcinogenesis has been the thrust of research for few decades.
Epigenetic alteration caused by the intrauterine environment may partly explain trait diversity, including disease phenotypes.
During each cell division, a new genetic or epigenetic alteration may emerge in one of the two daughter cells.
In addition, a consistent epigenetic alteration would be predicted for subsequent generations to the F3 (e.g. F4).
Aberrant promoter hypermethylation of TSGs and differentiation factors is a central epigenetic alteration in cancer [26], [27].
In the event the germ line has a permanent epigenetic alteration, a transgenerational epigenetic phenotype may be transmitted [1].
Epigenetic alteration indicates that targeted therapy against ALL is promising.
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