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The data presented here illustrate a heterogeneous epidemic which is consistent with the previous epidemiological studies in Kenya [24], [27], [37] [41].
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Interestingly, Ae. aegypti mosquitoes were the main vector in this initial epidemic [39], which is consistent with our observation that the E2-I211T mutation does not affect CHIKV infectivity for this vector.
We further assessed that the putative origin of the SARS epidemic was in late October 2002 which is consistent with a recent estimate using cases from China.
However, our results suggest that these O139 isolates from the then new epidemic have a single origin, which is consistent with earlier ribotyping data (15 ).
The transmission probability function is given as follows: The baseline transmission coefficient β was initially chosen to give an epidemic with an attack rate of 17.4% which is consistent with seasonal influenza.
The FMD epidemic was estimated to have had the largest effect in northwest England, which is consistent with the particularly large change in animal husbandry and livestock numbers associated with the FMD epidemic in this region.
In the baseline epidemic, this leads overall to 23% of infections being asymptomatic, which is consistent with an estimate for the 2009 A/H1N1 pandemic of 22% [26].
Finally, several members of the general secretory (Sec) pathway were highly induced, which is consistent with previous observations from an epidemic strain from the PHDC lineage, AU1054, under this condition [29].
Here, too, our results show that swift control of the epidemic on a local level is only achievable through a combination of control strategies, which is consistent with our results on the national level (fig. S3).
That steep rise, which is consistent through all segments of American society and which continued unabated through the 1990's, is the singular feature of the epidemic.
which is consistent with [16].
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