Pfizer also wanted to test the drug for use against meningitis, including an epidemic strain.
The low-medium-high bioinformatics resolutions were able to predict an epidemic strain of H5N1.
This strain, designated PHDC, lacks both B cepacia epidemic strain and cblA markers.
The new vaccine works against group A Neisseria meningitidis, the most common epidemic strain.
As shown in Fig. 2c, the results of three colorimetric reactions for each strain form a triplet pattern (no color change for absence of tcdC, one color change for wt-tcdC (non-epidemic strain), two color changes for ∆1stop-tcdC (epidemic strain 027/NAP1), and three color changes for TAA stop-tcdC (epidemic strain 078/NAP7)).
To enhance our knowledge about SLEV virulence, we performed comparative pathogenesis studies in Swiss albino mice inoculated with two different variants, the epidemic strain CbaAr-4005 and the non-epidemic strain CorAn-9275.
This study also showed the advantage of using a large genotypic database to predict the epidemic strain of H5N1.
The HRM10SNP assay accurately identified all 45 isolates as members of one of the three major clonal strains characterized by PFGE in two Brisbane CF centres (Australian epidemic strain-1, Australian epidemic strain-2 and P42) from 61 other P. aeruginosa strains from Australian CF patients and two representative overseas epidemic strain isolates.
Another epidemic strain of C. difficile, known as 078/NAP7, has also been described as hypervirulent since it can cause symptoms of similar severity to strain 027/NAP1.
Kelly, M. L. et al. Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection.
To facilitate antiviral drug discovery, we developed an infectious cDNA clone of an epidemic strain of EV71 and a stable eGFP reporter EV71.
