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Given the clear dependence of disease epidemic outcome on indirect transmission, improving our estimates of environmental prion survival and our ability to detect prions in the environment should increase our understanding of the disease and the effort needed for long-term CWD management and control.
Despite the presence of various other epidemiological factors that may influence the epidemic outcome, our results suggest that the variations of demographic and mixing profiles across countries are an important source of heterogeneity in the epidemic outcome.
As such, η represents an important source of country heterogeneity in the epidemic outcome, as already discussed.
Students who expected vaccination to prevent their own illness (outcome expectation 4; OR 2.8, CI 95%% 1.47 5.37) and those who expected that individual vaccination would help stop the epidemic (outcome expectation 7; OR 2.5, CI 95%% 1.32 4.67) were more likely to be willing.
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The epidemic outcomes for the alternative, more peaked (i.e. having higher hurtosis) infectivity profile exhibited three notable features that contrasted with that of the original infectivity profile.
The extremely slow and lethal dynamics of CWD have contributed both to the urgency and difficulty in predicting epidemic outcomes and effective control measures.
In contrast to linear models, epidemic models capture non-linear epidemic growth and can account for changes in epidemic outcomes due to interventions.
However, where a group of contacts is located and how it evolves in time can make epidemic outcomes differ from what would have been predicted at an abstract network level (Bertuzzo et al. 2010).
We found, however, that, for the specific set of parameters and distributions used, the presence of few individuals that become asymptomatic carriers over a considerably long time period (i.e., several months) has no significant influence on the predicted epidemic outcomes.
When data are collected over any time period which is less than the duration of the epidemic, the outcomes may differ from the outcomes that would have been obtained if the data were to have been collected over the entire epidemic, again through misclassifications.
To describe this epidemic and outcomes from outbreak response vaccination, we analyzed national surveillance data.
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CEO of Professional Science Editing for Scientists @ prosciediting.com