Curry, S. R. et al. tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficile.
Using near-real-time genome sequencing, we were able to show spread of the Canadian epidemic clone into the United States.
Eighty strains (51.9%) were susceptible to fosfomycin in BHIC, with minimum inhibitory concentrations (MICs) of ≤64 mg/L; 13 strains (8.4%) had the epidemic clone (EC) marker.
One could state that the MDR O12 clone is a genuine global epidemic clone.
LAC has been described and characterized previously [5] and is representative of the USA300 epidemic clone [47].
While some evolutionary lineages of the species are associated with health, others, including an epidemic clone, are strongly associated with moderate to severe acne.
They found evidence for an epidemic clone that is pathogenic to the eye and is characterized by a distinct combination of virulence factors.
Isolates whose patterns were indistinguishable or differing by no more than 3 fragments were considered to belong to the same epidemic clone.
This was expected as the infecting strain is a derivative of an epidemic clone and therefore can be considered as having all the necessary attributes to be potentially fully adapted and virulent to its host.
Their most potent strain belongs to ST18, the acne-associated epidemic clone of division I-1, while ST27 is the exceptional non-acne associated division I-1 clone with aberrant biotype, camp5 and tly allele, and α-glucosidase activity.
The population comprised three major divisions, one of which, including an epidemic clone, was strongly associated with moderate to severe acne while others were associated with health and opportunistic infections.
