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TOC Summary: An epidemic agent could have originated from such a cattle prion.
These features distinguish this serogroup from NmA and indicate that, in combination with poor immune induction by carriage, this serogroup may be a potential epidemic agent.
This difference between the 2 serogroups suggests that NmW135 may not replace NmA as the major epidemic agent in the future.
However, clarifying the etiology can be difficult, particularly for primary infections (e.g., HIV) that are characteristically associated with multiple opportunistic infections that may be more lethal than the epidemic agent itself.
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Furthermore, reporting and sample submission might have been more exhaustive and precise during epidemic situations, leading to overestimation of incidence and of the contribution of epidemic agents.
These findings demonstrate the capability of an atypical bovine prion to acquire classical BSE like properties during propagation in a homologous bovine prion protein context and support the view that the epidemic BSE agent could have originated from such a cattle prion.
At the beginning of the epidemic, the etiologic agent of this AHC outbreak was unknown.
This epidemiological interpretation of smoking turns the epidemic into the agent, and the people who smoke into mere vessels for its expression.
Sponges may be attacked by diseases of epidemic character, the agents of which are not well known.
The first one is the very accurate epidemic description with agent-based models, which keep track of each individual in the population in an extremely detailed way [ 3- 14].
When, on average, one infected person transmits an infection to more than one other person, R0 becomes greater than one, leading to sustained spread or epidemic spread of the agent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com