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EPA accepted the EDSTAC's recommendations for a two-tier screening program [9].
These components however, are not properly measured by current EPA accepted methods, such as the PM2.5 FRM, due to loss of semi-volatile material (SVM) from the filter during sampling.
Of the 334 tests proposed by sponsors in original test plans, the U.S. EPA accepted 223, rejected 49 as not needed, and substituted 62 tests that used fewer or no animals (Table 3).
In some situations the U.S. EPA accepted or rejected proposed animal-savings measures based on the sponsor meeting certain conditions, such as supplying study details in a robust summary or locating additional studies.
Surprisingly, sponsors proposed 18 new fish tests for chemicals that met the Kow criteria for use of Daphnia data, and the U.S. EPA accepted 16 of these test proposals, although sponsors subsequently dropped 6 of the proposed fish tests in test plan revisions.
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This committee accepted the assertion by the U.S. EPA that human exposure limits based on liver cancer would be sufficiently protective against cancer developing in other tissues.
According to the U.S. FDA, these are accepted because they used GLP (U.S. EPA 2008), with the implication that studies not employing GLP are not reliable or valid (U.S. FDA 2008a).
This is the currently accepted lowest adverse effect level (LOAEL) used by the U.S. EPA (U.S. EPA 1993).
More importantly, the EPA-PTP pipeline allows for deploying a widely accepted species concept to metagenomic data, where millions of sequences need to be processed.
We assumed a value of 0.5 × LOD for these samples, which is a generally accepted method of reporting data below the LOD (U.S. EPA 1999).
The committee had two meetings separated by 12 months, and after five drafts, adopted a report that accepted human testing subject to rigorous or severe limitations (U.S. EPA 2000).
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CEO of Professional Science Editing for Scientists @ prosciediting.com