Exact(17)
When combined with the target information, the enzyme information contributed more to the prediction than the transporter information.
There was a large increase in AUC for Set 1 through Set 6 when the PD-related information was integrated to the enzyme information (Set 20).
Results for Set 8 and Set 9, both integrating PK information regarding transporters and PD information (PKtr + PD), showed lower AUC than those for Set 1 through Set 6 which all included enzyme information.
The program used enzyme information from exPASy (http://expasy.org/enzyme/) and retrieved enzyme sequences from the UniProt database (http://www.uniprot.org/).org/
MetaCyc [39], the Multiorganism database of Metabolic Pathways and Enzymes provides a high-quality resource on small-molecule metabolisms and contains experimentally verified metabolic pathway and enzyme information curated from specialist literature.
Enzyme Commission number (E.C #) and enzyme activity are from the BRENDA enzyme information system [ 39].
Similar(43)
BRENDA [ 31, 32] is a database that gathers a very wide range of enzymes information mostly based on experimental data.
For six phase I and phase II enzymes, information about the influence of the polymorphisms on enzyme function was incorporated with genotype frequency in different ethnic populations to generate distributions of phenotypes.
Some of the entries include information about enzyme data obtained by enzyme purification and isolation.
Combining the metabolic enzyme inhibitor information in BRENDA database [ 10, 11] and enzyme product information in KEGG LIGAND database [ 12, 13], we constructed the inhibiting enzyme pairs dataset (see Methods).
In order to find the metabolic changes caused by the low doses of edelfosine, Isodyn simulated the isotopomer distribution using the available enzyme kinetic information and the experimentally acquired C isotopomer distribution data.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com