Exact(1)
If some knowledge of the relative activity of various enzymes for each reaction were integrated into this approach a more refined way of combining enzyme inferred changes could be used to score each reaction.
Similar(59)
In fact, among the set of enzymes inferred to have been already present in the LECA, a few are nonorthologous, but perform redundant functions, such as C-14 reductases (ERG24/FK), delta-8 delta-7 isomerases (ERG2/EBP), and delta-24 reductases (ERG4/DHCR24) (table 1 and fig. 4).
Compound pages display a set of name, pathway and enzyme annotations inferred from KEGG as well as the in silico predicted reactions that a compound may take part in as a reactant or product.
The existence of some enzymes is inferred due to the presence of others and the presence of end-products.
The broad substrate spectra characteristics of these modification enzymes were inferred.
Indeed, 33% of all identified metabolic enzymes are inferred to function in carbohydrate biosynthesis, and the majority are predicted to be localized to the plastid (table 2, supplementary table S1, Supplementary Material online).
Translocation and force generation by the wild-type and mutant XPD enzymes were inferred from their ability to facilitate streptavidin displacement from ssDNA oligonucleotide biotinylated near the 3′-end (Morris et al, 2001; Pugh et al, 2008a).
While these enzymes are inferred to mediate or modulate proteolytic functions, they may in turn, facilitate the nematode's interaction with its host and symbiont, as the proteinase inhibitors may protect the nematodes against its host's immune system.
While these enzymes are inferred to mediate or modulate proteolytic functions, which, in turn, may facilitate tissue migration and other interactions with host cells, the proteinase inhibitors may protect the parasite against digestion by host or endogenous proteinases excreted/secreted in the lung of the mammalian host [ 39].
Freilich and collaborators have recently conducted a survey and analysis of enzymes in 85 genomes [ 17]; however, they have inferred enzyme function using strategies based on sequence similarity alone, which suffer from the problems mentioned above.
Normalized enzyme levels were inferred from the microarray time courses described above.
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