While Ju and co-workers stress that the NMR enzyme models in the vicinity of the metal cofactors should be used with some caution, they point out the interesting possibility that the distinct active site geometries of the structures very well rationalize the distinct reactivities of Ni II)- versus Fe(II -ARD.
Five malarial enzymes appear in the vicinity of the TyrK-like group, including two [MAL6P1.191 and PFB0520w] that display maximal homology to MAPKKK-related or MLK (mixed-lineage kinases) enzymes upon BLASTP analysis.
Subsequently, LAT establishes a cooperative network of cytoplasmic signaling proteins such as the adaptor protein Grb2 and signaling enzyme PLCγ in the vicinity of activated TCR [5].
Consider first conditions in which the number of PEP molecules is 2000 and in which metabolons allow the products of one enzyme to be released in the vicinity of the adjacent one; that is, channeling is not obligatory, and metabolites can escape from the metabolon.
Because USP7 has multiple roles in the DDR, an important role of UVSSA might also be to deliver the deubiquitinating enzyme to the vicinity of TC-NER factors, allowing smooth regulation of ubiquitination and deubiquitination.
Histone modification occurs in cis, when the lncRNA recruits the histone-modifying enzymes to the genes in the vicinity of the site of lncRNA transcription.
It is yet unclear how a host-specific cuscutain activity is achieved, since the enzyme is most likely localized in the vicinity of host and Cuscuta tissue.
Docking studies confirmed previous assumptions 6b that in the case of formation of regioisomer 3, the 3′-hydroxyl moiety of the substrate 1 pointed out of the enzyme to the solvent and is not in the vicinity of any residue of the enzyme backbone.
One possibility is that a conformational change resulting in exposure of the critical Cys of ND3 involves other accessory subunits of the eukaryotic enzyme in the vicinity, e.g. 39 kDa subunit or B13 [ 19, 20].
One of the other two enzymes could also process ligand in the vicinity of iridophores leading to some residual signalling activity via the rse receptor in kar mutants.
