Sentence examples for enzyme environments from inspiring English sources

In an effort to design an assay paradigm for the development of JAK2 selective inhibitors, we investigated whether compound selectivity differed between cellular and purified enzyme environments.

Hence, particularly in relation to the popular techniques of XAFS and XANES (X-ray absorption near-edge structure), this development calls for strong theoretical involvement but has great applications in solid state structural determination, catalysis and enzyme environments, active centres of biomolecules and organometallics, phase changes and fluorescence investigations and others.

We conducted a comparative study of the GOx kinetic parameters as a function of the enzyme environment; i.e., in solution and immobilized onto carbon platforms.

These results suggest that targeting of the occluding loop of cathepsin B may be a poor inhibitor design strategy if the enzyme environment has a pH greater than 5.5.

There are two key requirements for reliably simulating enzyme reactions: one is a reasonably accurate potential energy surface to describe the bond-forming/breaking process as well as to adequately model the heterogeneous enzyme environment; the other is to perform extensive sampling since an enzyme system consists of at least thousands of atoms and its energy landscape is very complex.

In addition, the partition of substrate on the enzyme environment is also responsible for that.

The pKas of basic and acidic amino acid sidechains can be significantly altered in the enzyme environment.

In addition, the nature of the support and its polarity can also affect the enzyme conformation, as well as the partition of substrates and products from the enzyme environment, which might prevent the access of the substrate to the enzyme active site.

Interestingly, these effects of bulky substituents were later reproduced by quantum mechanical calculations in the absence of the enzyme environment.

Turning the switch "on," the enzyme environment becomes the driving force to impose a distinct conformation of the 5′-deoxyadenosyl radical to avoid deleterious radical transfer.

Therefore, the results from gas phase calculations indicate that this conformational change is intrinsic to Ado· and independent of the enzyme environment.