The CYP19 gene encodes the enzyme aromatase, which plays a key role in the conversion of androgens to oestrogens.
One explanation--the one the researchers embrace--is found in the fact that breast tissue can manufacture its own estrogen via the enzyme aromatase.
Consequently, suppression of oestrogen action by inhibition of their biosynthesis at the androstenedione-oestrone aromatization step, by means of selective inhibitors of the enzyme aromatase, has become an effective therapeutic option for the treatment of hormone-dependent breast cancer.
The enzyme, aromatase, converts testosterone into estrogen in the stomach.
Adipocytes secrete factors important to bone remodeling, such as the estrogen synthesis enzyme, aromatase, and proinflammatory cytokines [12].
The conversion of T into E2 is catalyzed by the enzyme aromatase [6] [8] which exhibits a very discrete distribution in the brain.
The canonical view, derived from studies of rats, emphasizes conversion of T to estradiol (E2) by the enzyme aromatase as a key step in nervous system maintenance of MSB.
However, known sex differences do exist in a specific subset of GABAergic neurons in zebra finch NCM [21], and the distribution of these neurons is similar to that of mRNA expression for the estrogen-generating enzyme aromatase [22].
In many vertebrates, the neural conversion of testosterone into estradiol by the enzyme aromatase plays a key role in the sexual differentiation of brain and behavior [4], [5], [6], [7] and in the activation of masculine sexual behaviors in adulthood [8], [9], [10].
The enzyme aromatase is highly present in endometriomas [ 74].
Oestrogen synthesis is catalysed by the enzyme aromatase cytochrome P450.
