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This special force can activate the enzyme by increasing the enzyme affinity with the substrate (Juneidi et al. 2017).
Thus, statins can decrease all three end products but, as a consequence of enzyme affinity, mainly reduce cholesterol production.
Structure-activity relationship studies allowed the identification of the better structural features for enzyme affinity.
We conclude that the intermolecular interactions in the hydrophobic tunnel dominate enzyme affinity in this series of benzoic acid derivatives.
The surfactant alleviated the inhibitory potential of fillers by reducing enzyme affinity towards the fillers and resulted in increased enzyme availability in solution for the cellulosic fibers.
Kinetic study also indicated that the enzyme affinity to assay substrate was maintained after immobilization when compared with packed bed and batch reactors.
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Estimated Km values of 1.4 mM for EpiDerm™ and 2.0 mM for PFT reflect correlated enzyme affinities.
When two substrates share the same pool of APC/CCdc20, their relative enzyme affinities and rates of catalysis influence the partitioning of APC/CCdc20 among substrates, resulting in substrate competition.
Due to its hierarchical integration structure, it is readily extensible to include other relevant similarity measures if available (e.g. enzyme affinities), or to modify a component score (e.g. using compound molecular similarity scores).
For the amino compounds, in addition to the cyclohexyl and cyclopentyl examples 8h and 8n at 84 and 115 nM, the substituted phenylethylamines 8k and 8l showed promising enzyme affinities of 74 and 64 nM, respectively.
Mutation of the basic residues that coordinate the 3′-phosphate in HsPPT significantly decreased the mutant enzymes' affinity for CoA, with a modest increase in catalytic turnover.
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