Sentence examples for enzymatic screening from inspiring English sources

In addition, the enzymatic screening result demonstrated that the optimized compounds possessed potent Raf kinase inhibition as well as favorable enzyme selectivity.

Enzymatic screening of ΔfopC revealed aberrant acid phosphatase activity and localization.

Given the low sensitivity of the enzymatic test for identifying heterozygous females, a significant number of females may be placed at risk of hemolysis if enzymatic screening is utilized in such settings [38].

These solutions can potentially make this platform suitable for a broad range of enzymatic screening.

For this, we established a high-throughput enzymatic screening assay for DAPK1.

Enzymatic screening was based on detection of the (relative) activity of exo-chitinases (β- N-acetylglucosaminidase and chitibiosidase).

Most of these imidazopyridine derivatives displayed nanomolar potency against c-Met in both biochemical enzymatic screens and cellular pharmacology studies.

The phenotypic data presented herein may form the basis for selecting scaffolds/compounds for further enzymatic screens against specific kinase or other ATP-binding targets in Mycobacterium tuberculosis based on the apparent activity against the whole bacteria in vitro.

Application of general enzymatic screens and substrate profiling can greatly speed up the identification of biochemical function of unknown proteins and the experimental verification of functional predictions produced by other functional genomics approaches.

After pharmaceutical manufacturer Pfizer completed an enzymatic screen, the company identified two new enzymes which eliminated several chemical conversion steps, increased production speed, and reduced waste [ 31].

In order to provide functional insights into the medically relevant rTSβ and facilitate future studies, we isolated recombinant human rTSβ and rTSγ isoforms, identified rTSγ as an l-fuconate dehydratase using a medium throughput enzymatic screen, and determined the crystal structure of rTSγ at 1.74 Å resolution.