Dysregulated pH, one of the most remarkable hallmarks of tumor microenvironment, can be considered as a good specific trigger for the design of broad-spectrum and local-environment responsive imaging probes.
Moreover, CMSN-A exhibits dual micro-environment responsive (lower pH, more reducing substances) due to the redox-sensitive disulfide bond and pH-sensitive amide bond in the short chain ammonium group.
Due to the different swelling behaviors of the core and shell materials in acetonitrile and water, the PMAA/PNIPAM microgels with the same chemical composition and crosslinking degree showed the similar morphology, but different particle size as well as drug-loading and environment responsive release performance.
The integration of sophisticated drug delivery technologies such as nanotechnology-based ones with intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes.
The theory is this: as products make the built environment responsive to humans, environments become friendlier, more approachable, and perhaps begin to leverage technology to rejuvenate employees.
Many CREs are environment responsive motifs, for example, MYCCONSENSUSAT for cold [ 36- 38], WRKY71OS for gibberellin and pathogenesis [ 39, 40], ACGTATERD1 and IBOXCORE for light [ 41, 42], MYBCORE for water stress [ 43], GT1GMSCAM4 for pathogen and salt [ 44] and WBOXNTERF3 for wounding [ 45].
These features make them potential DDS for tumor-environment-responsive controlled release.
A ligand decorated, synthetic polypeptide block copolymer platform with environment-responsive capabilities was designed.
Innovation in material chemistry allows the generation of biodegradable, biocompatible, environment-responsive, and targeted delivery systems.
We report the unique environment-responsive fluorescence of nitrophenyl or nitrophenylethynyl oligothiophene derivatives with different numbers of thiophene rings.
