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The MetS and energy dysmetabolism are modulated by a number of factors including the psycho-social [ 9, 17] and environmental; locality [ 18]; food systems; physical activity patterns, biological rhythms (sleep, leisure and work, and sunlight exposure which affects vitamin D status) and pollutants [ 12].
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The only exceptions to the issue of inflated AUC values in our dataset are P. p. colemani (AUC = 0.917) and P. p. polionotus (AUC = 0.851), which are the only two widely distributed subspecies spanning a more heterogeneous environmental space where locality information for the subspecies is not geographically clustered.
This could be due to lower genetic connectivity for populations of the Su morph, and also to environmental differences between localities.
Maxent is used to estimate a probability distribution by comparing the environmental conditions at localities in which disease transmission was recorded with environmental conditions across the landscape (34, 35 ).
Niche models are based on environmental values at localities of known occurrence of the target taxa, which then are used to identify geographic regions that have similar combinations of values.
Maxent operates under the maximum-entropy principle, which seeks to generate a probability distribution of habitat suitability that is closest to uniform (i.e., with equal probabilities of occurrence in all map grid cells) but subject to the constraints imposed by sets of environmental values at localities of known occurrence of the species.
GARP is based on a genetic algorithm and is used to find a set of rules describing nonrandom associations between localities where disease transmission has been reported and environmental conditions in those localities (32, 33 ).
The simulations indicate that only the most extreme scenarios are capable of producing perturbations that are likely to have environmental consequences beyond the locality of a leak event.
11 The high prevalence of allergic rhinitis was postulated to be related to outdoor environmental pollutants in our locality.
Finally, environmental factors included place (locality) of residence (rural vs. urban) and province of residence of the respondents.
Finally, environmental factors included place (locality) of residence (rural versus urban) and region of residence of the women, including her ethnicity.
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