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On the contrary, the effects of environmental ligands (e.g., bicarbonate, chloride, humic substances, phosphate, sulfate) and other common ions (e.g., chlorate, fluoride, nitrate, nitrite) can be investigated in a way that more transferable results are achieved.
As a result, the concentration response relationships and relative activities of FM 550 at PPARγ were investigated in more detail with the contribution of each chemical component defined and compared to the activities of the prototypical PPARγ environmental ligands triphenyltin and tributyltin.
Structural and functional profiling of environmental ligands for estrogen receptors.
Such activation might be triggered by environmental ligands and be associated with non-oncogene addiction to these pathways.
This observation, together with our finding that ER environmental ligands may act in a subtype-specific fashion, suggests that different xenoestrogens could have different impacts on cancer incidence.
Together, these experimental data provide a structural rationale to explain the functional properties of the environmental ligands of ERs at a near-atomic level.
Similar(46)
The rates of the transition reactions are dependent on the environmental ligand concentration.
Therefore, the nonadaptive fluctuation can carry information of the environmental ligand concentration.
Mutant II shows a large fluctuation and a heavy-tailed distribution of run length irrespective of the environmental ligand concentration.
The model exhibits a nonadaptive fluctuation sensitive to the environmental ligand concentration, while perfect adaptation is achieved on average.
While the activity shows adaptation on average, its temporal fluctuation is a nonadaptive property, which is sensitive to the environmental ligand concentration.
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