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Induction of a chromatin environment permissive for acquiring neuronal subtype identity is therefore a major barrier to fate conversion.
Crotta, S., Brazzoli, M., Piccioli, D., Valiante, N. M. & Wack, A. Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection.
A fraction of these constituent cells are then randomly sampled and seeded into a new flask containing an environment permissive for cell division (Figure 1).
This analysis demonstrates that IhNSCs efficiently survive in vivo and that their engraftment and migration capacities are improved in a lesioned brain, which is consistent with previous results showing that injury generates a local environment permissive for the integration of xenotransplanted cells [17], [29], [32].
Hence, the conditions during regeneration are not inconsistent with an environment permissive for p53- induced senescence.
Under a Th2 polarizing cytokine environment, permissive histone modifications are lost at the IFN γ locus by DNA methylation.
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Previous studies have shown that bone formation depends on three osteogenic factors [ 8]: 1) a certain number of bone marrow mesenchymal stem cells; 2) effective inducing factors; and 3) the presence of a micro-environment permissive for new bone formation.
Lethal equivalents for MPS were 3.45 in the permissive environment and 6.71 in the stressful environment.
Our conclusions are based on the assumption that both types of selection will have occurred in both environments, but that directional selection was weak in the permissive environment.
Experimental aquariums were established as matched pairs, one serving as a control (permissive environment) and one subjected to low salinity (stressful environment).
Using LC, the number of lethal equivalent loci in the permissive environment was 2.87 compared to 10.97 in the stressful environment.
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