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Understanding which environmental factors can affect DNA methylation and elucidating the functional significance of DNA methylation in these important bioindicator species will be major steps toward clarifying the complex interactions between the environment, gene expression, and organismal responses.
Much of our analysis focuses on the analysis of a wide range of potential correlates to YRV, including components of gene structure, chromatin environment, gene expression and function, and gene evolutionary patterns.
In general, the frequency of successful DNA exchange between bacteria belonging to different genera will depend on many factors: the degree of homology between the transferred DNA and the bacterial host, the metabolic compatibility, adaptations to their abiotic environment, gene expression systems, gene-transfer mechanisms, the mismatch repair and restriction endonuclease systems.
Recent advances from Drosophila have provided insight into the complex relationship between nutritional environment, gene expression and metabolism (Birse et al., 2010; Bujold et al., 2010; Fujikawa et al., 2009; Horner et al., 2009; Musselman et al., 2011; Ruaud et al., 2011; Sieber and Thummel, 2009).
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DOI: http://dx.doi.org/10.7554/eLife.05856.002 Many studies over the last decade have established that, even within homogeneous environments, gene expression varies across genetically identical cells due to thermodynamic fluctuations in the molecular events underlying gene expression and the small numbers of molecules involved (Elowitz et al., 2002; Rao et al., 2002).
We describe the type of information that can be obtained from candidate gene and genomic studies that incorporate environmental factors in the design (i.e., gene – environment interaction and gene-environment correlation studies) and studies that capitalize on the idea that environment modifies gene expression, via epigenetic or other molecular mechanisms.
Effects of the environment on gene expression are referred to as gene-by-environment-interactions, and the response displayed by organisms to such environmental change, phenotypic plasticity [ 1].
Not only the cellular environment affects gene expression and protein production, but the individual's relationships with the environment may also influence aspects of behavior, morphology and gene expression, even in a matter of hours [ 32].
It may also be the case that there are individual differences in sensitivity to the socioemotional environment, such that certain alleles are associated with a stronger relation between environment and gene expression.
Our results also suggest that the rice plants are suitable plant models for further research of the effects of the space environment on gene expression and function.
This coupling is dynamical, and can be regarded as a description of the dynamical coevolution between chemical changes in the intercellular environment and gene expression within the cell.
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