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"If the envelope has broken down and the silicone has leaked out, you are trying to get out all of that goo," said Dr. Susan E. Kolb, a plastic surgeon in Atlanta who performs three to five explantation surgeries a week.
When compared to reporters containing nuclear localization sequences (nls), histone fusions exhibit an improved signal-to-noise ratio and have the distinct advantage of signal remaining bound to the target even during cell division when the nuclear envelope has broken down.
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The ice has broken.
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Water mains had broken.
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