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Box 1. Clinical settings and endpoints With these numerous non-interventional studies published, interventional controlled "phase III" trials were needed to demonstrate that the use of CTC enumeration and monitoring could improve the outcome of breast cancer patients and/or lower the medical costs paid by the patient or its insurer.
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Monitoring of cancer associated bone events by RNB with the fine soft-tissue detail afforded by MR is expected to decrease false-positive lesion enumeration and improve disease monitoring.
The 'liquid biopsy' approach based on the monitoring, enumeration and molecular characterization of CTCs is rapidly becoming a valuable tool in translational medicine, especially for the prediction of therapeutic efficacy in cancer patients.
Enumeration and characterization of these cells may increase early detection, improve design of personalized therapies and monitoring of treatment efficacy, enhance prognostic accuracy, and advance our understanding of the biology of metastatic disease.
Beyond enumeration, the characterization of these cells has the potential to improve risk assessment, treatment selection and monitoring, and the development of novel therapeutic agents, and to advance our understanding of the biology of metastasis.
Enumeration of CTCs in the peripheral blood of cancer patients has shown promise for the diagnosis and monitoring of cancer progression, and it serves as an alternative to conventional imaging methods.
Security and monitoring.
An ideal CTC analysis platform would provide unambiguous morphology for definitive CTC identification, comprehensive CTC enumeration for monitoring a patient's response to therapy, flexible characterization of biomarkers (including drug targets), and also enable isolation of CTCs for molecular analyses.
Rehabilitation and monitoring.
The key variables in enumeration are (a) the starting area for enumeration and (b) the order in which the areas are enumerated.
CTC Immunostaining, enumeration, and PD-L1 expression analysis.
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