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Intravenous (IV) cocaine HCl has almost immediate behavioral and cardiovascular effects, effects that have been assumed to result from its rapid entry to the brain [13], [14].
Transport vectors could activate natural transport rout and enhance entry to the brain.
There is a potential for neurodegenerative consequence of particle entry to the brain.
For drugs with high BBB permeation such that entry to the brain via the BBB capillaries is rapid, cerebral blood flow becomes rate-limiting.
These experiments also confirm previous data suggesting that the change in concentration gradient (and passive driving force) plays a minor role in glucose entry to the brain under conditions of functional brain activation.
Such strains usually target microglia or macrophages (not astrocytes), and may gain entry to the brain by entering it within infected T-lymphocytes (the 'Trojan horse' hypothesis of CNS infection).
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Considering the current usage of NECT, it is somewhat surprising that very little is known about the mechanisms being used by these drugs to gain entry to the human brain.
Although only rare subsets of these cancer patients ever develop PND, it would seem that reliance on ignorance of neuronal proteins would pose a potentially great immunologic risk, as neurons induce MHC I molecules during inflammation, at the same time that activated T cells are allowed entry to the CNS across the blood brain barrier [3], [5], [28], [29].
"Music might provide an alternative entry point" to the brain, because it can unlock so many different doors into an injured or ill brain, said Dr. Gottfried Schlaug, a Harvard University neurologist.
In infants, the putative portals of entry to the blood could be dermal, oral, or respiratory; and entry of such circulating small molecules to the brain are via the blood-brain barrier, blood-cerebrospinal fluid barrier, and circumventricular organs.
Therefore, we argue that chemotaxis of granulocytes or entry of granulocytes to the brain is not induced upon programmed cell death in the brain.
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