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This spontaneous intramolecular urea bond forming reaction has not been studied so far and might represent an interesting entry to novel cyclic peptide scaffolds.
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If you think of a novel as a complicated machine, then one of the best ways to understand how it functions -- to determine what makes its component parts cohere and smoothly whir along -- is to ask yourself a simple question: "Who is telling us this story?" The answer, nine times out of ten, provides an entry to the novel's inner workings.
There were some old Pepto Bismol bottles, plastic maple syrup containers and thousands upon thousands of pages of text and images, from diary entries to epic novels to comic-style drawings of big adventures starring little girls.
Events such as handball are worth a punt – plenty of sessions and relatively cheap tickets (from £20) will combine entry to the park with a novel experience.
Rather than portraying Yorktown and subsequent setbacks as anomalies in an arc of imperial ascent, Brendon uses this novel point of entry to reinterpret the British empire as an enterprise whose validity was persistently challenged, from within and without.
Key to novel entries into drug design programs at this receptor is to reveal the structural determinants of chemical recognition of serotonin and other ligands at 5-HT3R by supporting X-ray crystal structures.
34 of the identified protein spots are novel entries to the Anabaena salt proteome.
On the basis of these pioneering experiments, and the recent demonstration that Drosophila can be used to identify the core regulatory network that contributes to the development of AML (Osman et al., 2009; Sinenko et al., 2010), it is expected that more genetic screens performed in flies will provide novel entries to the study of acute and chronic leukaemias in mammals.
Most recently, within the context of the European IMPACT project, PRINTS became more tightly integrated with InterPro: as well as providing new entries to the resource, a novel hierarchy-based filtering approach was developed, helping PRINTS meet InterPro's automated sequence analysis requirements by resolving protein family membership as unambiguously as possible.
The sentence quoted above is in fact part of a Starbucks "Reach for the Stars" writing competition entry attributed to the novel's protagonist, Amina, a Bangladeshi woman who has immigrated to America.
These provide an entry point to try to identify novel genes linked to human CHDs as illustrated [ 22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com