Both PACCE and CAIRO 2 did not pre-select patients with wild-type K-ras tumours, the US Intergroup study, CALGB 80405, had amended the entry criteria to exclude patients with K-ras mutations and hopefully this would be able to answer definitely whether synergy exists between cetuximab and bevacizumab in wild-type K-ras patients.
The study overcomes limitations in prior studies in that it (1) assessed personal characteristics before study entry in order to exclude "contamination" effects, (2) selected an appropriate control group, and (3) differentiated between STEM and non-STEM study majors.
A structural model of human Rac1 from X-ray crystallography [Protein Data Bank (PDB) entry 3TH5], modified to exclude bound nucleotide and magnesium, served as a molecular replacement search model using PHENIX AutoMR.
All the sequences were screened to exclude entries that were related to patents, artificial mutants, and identical sequences.
Therefore, we decided to exclude this entry from the dataset.
External openings were closed by using wire hardware cloth to exclude squirrel entry.
We therefore decided to exclude this entry from the estimation of the success rate.
Furthermore, the inadequacy of the proximal sealing zone has been reported to be a main cause of failure to exclude the entry tear or aneurysmal sac, especially when the tear or aneurysmal sac is located at the outer curvature of the aortic arch [ 20], potentially resulting in a type Ia endoleak.
We subsequently performed pair-wise sequence comparisons to exclude redundant entries from the initial data set, which is frequently caused by multiple identification numbers of the same DNA or protein sequence in the databases.
In the NCBI Gene subset parsed and loaded into GeneBase, the majority of gene entries does not belong to C. elegans or to A. thaliana (Taxonomy IDs: 6239 and 3702, respectively), unlike for example in ExInt and in IDB and IEDB, but to H. sapiens (Taxonomy ID: 9606), in agreement with the current choice to exclude gene entries with a 'MODEL' RefSeq status.
All women underwent a chest radiograph, bone scintigraphy and liver ultrasonography to exclude metastases before entry.
