This might be reflected in faster total analysis time and shorter entry time (time from case onset until the region of interest [ROI] is visually localised).
Patients were assumed to have entered the study at some point during a one-year period, with their entry time generated from a uniform distribution between time zero and 1 year.
In the past, the primary endpoint in clinical trials of MS has been the annual relapse rate, the change in a clinical indicator such as the Expanded Disability Status Scale (EDSS) score or total area of MS lesions on the MRI scan from entry time, the proportion of non-relapsed patients, or the time to the first recurrence [ 1, 2, 5- 10].
If all the patients are followed from their entry time to the analysis date, the Kwak and Jung's design leads to a smaller sample size as compared to the Case-Morgan's design.
One model measures from the entry time and is called the total time model (PWP-T model).
Patients were followed from cohort entry (time when they fulfilled the RA case definition) until their first joint replacement surgery, or were censored at death date, or the end of study period (31 December 2011), whichever came first.
Thus, in order to be eligible to enter the ICS group they must have survived at least as long as the interval from hospital discharge (which was defined as the cohort entry time) until ICS were prescribed and during this time they were effectively immortal as they could not die, whereas patients not in the ICS group could die at any time from cohort entry.
Quantitative comparisons of delay were determined on the basis of normalized integrated postsynaptic charge entry vs time from the start of stimulation.
Patients were centrally randomised either to tamoxifen (40 mg/day) or supportive therapy using a minimization procedure with center, evidence of disease at entry and time from HCC diagnosis as stratification variables.
To obtain the NDT from our model, we subtract the exit times from the entry times of CP reaching '1' and this NDT is called as cumulative probability NDT (N D T CP ) (i.e. NDT derived from CP).
