Sentence examples for entry of substances from inspiring English sources

Blood brain barrier (BBB) together with enzymes restricts the entry of substances for maintaining the internal milieu of the brain.

Similarly, P-gp in the blood brain barrier limits the entry of substances into the brain (Schinkel et al, 1994, 1996).

Since solubility, not molecular size, was the best predictor of the entry of substances in the cell, Overton favored Nernst's hypothesis for membrane permeability [ 68].

(iv) Astrocytes may also modulate the microvasculature, leading to vascular permeability and promoting entry of substances such as albumin or circulating leucocytes into the brain parenchyma with consequent seizure promoting effects (de Lanerolle et al., 2010).

The blood-brain barrier (BBB) prevents entry of neurotoxic substances but also that of drugs into the brain.

Cell membrane is a protective hydrophobic barrier in a living cell, which prevents the free entry of extracellular substances and makes the intracellular environment relatively stable to guarantee the orderly operation of various intracellular biochemical reactions (Szostak et al., 2001).

Endocytosis is the general mechanism by which cells regulate entry of external substances into the cell and represents an important route for delivery of targeted therapeutics for a variety of pathologies including cancer [1].

Brain is considered a privileged site for the presence of blood brain barrier (BBB) protecting it against the entry of toxic substances and microorganisms [ 12, 13].

For example, in the clinical setting, in vivo, in vitro, and human experimental evidence combined with an analysis of risks and benefits have informed human exposure decisions prior to the the entry of the substances into the marketplace.

Intracellular remodelling of epidermal keratinocytes, also known as cornification, proteinaceous connections between terminally differentiating cells, and the establishment of an extracellular lipid compartment are critical processes in establishment of the barrier against water loss and to the entry of noxious substances from the environment (1– 3).

In epilepsy, changes in the brain internal environment can temporarily destroy the integrity of the BBB; when the expression of P-gp is increased in the BBB, the function of the BBB can be maintained to prevent the entry of harmful substances into the brain [ 7].