Sentence examples for entry of compound from inspiring English sources

Moreover, the selective index of inhibition on entry of compound 9a3 (>6.25) was higher than that of ARB (6).

The PGP transporter is a major barrier to the entry of compounds to the CNS.

Firstly, the macrophage-like coelomocytes are active in fluid-phase endocytosis and pinocytosis, which facilitate the entry of compounds into the cell.

The central nervous system is protected by barriers which control the entry of compounds into the brain, thereby regulating brain homeostasis.

The human multidrug resistance transporter P-glycoprotein (P-gp) prevents the entry of compounds into the brain by an active efflux mechanism at the blood brain barrier (BBB).

This is mainly due to the decrease of dispersive interaction, more water cluster formed to block entry of compounds into micropores or competition between water and compounds adsorbed onto the surface of ACF because of hydrophilic increase of ACF.

The first step involves the passive entry of compounds being ampiphillic in nature into plasma membrane in order to initiate membrane disruption by altering fluidity and integrity because of reduction in the ergosterol synthesis.

61 Another key factor restricting the entry of compounds into the CNS is a drug polar surface area (PSA) value higher than 80 Å.

The crucial point is to reduce the time lag between market entry of a compound and its identification and classification.

As observed for cisplatin [ 30, 31], we found little difference in the cytotoxicity of C7a in murine melanoma B16F10-Nex2 cells at 4°C or 37°C, suggesting a passive entry of the compound in tumor cells.

Although Trp competes with kynurenine for cerebral uptake (see Møller, 1985 and references cited therein), the above proportionate increases are unlikely to cause an imbalance in entry of either compound into the brain.