Exact(24)
The genes encode proteins that facilitate virus entry into human cells, and one that mediates cell aggregation, which allows the virus to spread between cells.
CCR5 encodes a chemokine receptor required for HIV-1 entry into human cells, and individuals carrying mutations in this gene are resistant to HIV-1 infection.
The AACs play an important role, not only as HIV-1 RNA binders but also as inhibitors of viral entry into human cells.
Scientists at Columbia were the first to identify the CD4 receptor that the virus uses to gain entry into human cells.
HIV-1 (human immunodeficiency virus type 1) uses its trimeric gp160 envelope (Env) protein consisting of non-covalently associated gp120 and gp41 subunits to mediate entry into human T lymphocytes.
She then used them to encapsulate a mainstream antibiotic and, with fluorescence microscopy, visualized their entry into human cells.
Similar(36)
The most clearly defined milestones in the drug discovery process are project initiation and entry-into-humans.
The current entry-into-humans study was performed to investigate the pharmacokinetics, pharmacodynamics and tolerability of ascending single doses of this new compound in healthy male subjects.
To estimate the possible date of STLV-4 entry into humans, detailed Bayesian phylogenetic analyses were performed.
The discovery of NTCP as entry factor into human hepatocytes has paved the way to facilitating molecular studies of the complete HBV life cycle, but the downregulation of innate immune factors in cell lines restricts the study of host/pathogen interactions and disease pathogenesis to PHH cultures.
This variation in sialic acid expression may provide an opportunity for AIVs to infect certain individuals as entry points into human population, which provide a chance for further adaptation, which will enable the virus to gain full access into human population.
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