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Progression-free survival was calculated from entry in the study to progression or death from disease (or end of follow-up if not progressed).
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Sixty one practitioners were identified by the insurers as likely to be non-compliant prior to entry in the study.
Pretreatment with an antidepressant and/or mood stabilizer medication had to be stable for at least 4 weeks prior to entry in the study and remain unchanged throughout.
Informed consent was obtained from all patients prior to entry in the study.
Prior radiotherapy and chemotherapy must have elapsed a minimum of 4 weeks prior to entry in the study.
Despite the high response rate, there might still be a non-response bias; the participation was asked during mandatory educational initiatives but PCPs can refuse to entry in the study.
All patients provided written informed consent prior to their entry in the study.
In the period up to 2 years after entry in the study, 59 deaths were identified in S. Typhimurium patients and 221 deaths among 20,456 referents.
The mean age at entry in the study was 40.9 years; 72% of the women had a low to intermediate level of education.
Patients (141) requesting emergency contraception and lacking contraindications were offered entry in the study.
Each patient underwent a high-resolution T1-weighted volume MRI scan both at entry in the study and 18 months later.
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