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The individual entry hypothesis would require individuals or small groups to enter repeatedly and succumb to some form of, as yet unidentified, mortality event.
Some of these results form the basis for the "sorting for entry" hypothesis, which proposes that regulated secretory proteins are sorted into ISGs in the TGN, while constitutively secreted proteins enter CSVs (see review Tooze 1998).
These results provided the first demonstration that regulated secretory proteins and constitutive secretory proteins were sorted into two distinct vesicle populations directly upon exit from the TGN, in support of the "sorting for entry" hypothesis.
Similar(57)
The cyclic re-entry hypothesis was first proposed based on considerations of the efficiency of affinity maturation using an ordinary differential equations model for B cell population dynamics.
A surprising number of modifiers identified from the screen play a role in regulating the cell cycle or chromatin binding, lending further credence to the mitotic failure/cell-cycle re-entry hypothesis of neurodegeneration.
Analysis of crystal structures of both A- and B-type KRs led to a corollary to the direction-of-entry hypothesis by noting that cofactor binding (NADPH or NADP+) in A-type KRs may generate a tight and well-ordered conformation at the active site through a hydrogen bonding network.
Large portions of the entry on "hypothesis" are lifted almost verbatim from chapter 4 of her Foundations.
Noël and Seron [ 22] developed a "preferred entry code" hypothesis.
Second, supplemental dTMP and dCMP failed to fully correct intra-mitochondrial levels of dTTP and dCTP, indicating that mitochondrial membranes impede dNTP entry; this hypothesis is supported by the low intra-mitochondrial dCTP/dTTP levels with normal cytosolic concentrations of dCTP and dTTP in liver of 29-day-old treated mice.
This led to the formulation of the synaptic re-entry reinforcement hypothesis (SRR), which posits that memory consolidation requires delayed reactivation of the NMDA receptor to convert short-term memory into long-term memory.
Results will be reported as baseline R for the reference group, and incidence rate ratios for all other entries and hypotheses were tested at α=0.05.
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