Exact(9)
Notably, CLDN-1 is a HCV entry factor and confers HCVcc and HCVpp entry.
Using a chemical biology strategy, we have demonstrated that 5-HT2AR is a HCV entry factor that functions in the late endocytosis stage at or before membrane fusion.
Here we identify serotonin 2A receptor (5-HT2AR) is a HCV entry factor amendable to therapeutic intervention by a chemical biology strategy.
We were able to infect mouse cells expressing human CD81 and occludin (OCLN the minimal set of entry factor factors required for HCV uptake into mouse cells.
Interestingly, CLDN-1 is the first entry factor shown to confer susceptibility to HCV when ectopically expressed in non-hepatic cells.
Notably, the one Huh7 cell line we found to be relatively non-permissive, the Huh7-6 celineine, has also down-regulated an essential HCV receptor, SR-B1, and perhaps another yet unidentified entry factor.
Similar(51)
Herein, we describe the effects of a set of statins on HCV entry and on HCV key entry factors in vitro.
The exit factors in the herd dynamics prevailed over the entry factors, and this was not favourable for herd re-building and maintenance.
It aims to clear the principal criteria of measuring inventive efficiency, and demonstrates the necessity of a pertinent selection for entry factors to define indicators.
We thus hypothesized that the loss-of-function of 5-HT2AR malterthe the correct membrane distribution of HCV receptors or entry factors.
Similar to what has been observed for other HCV receptors or entry factors (Sainz et al., 2012), we observed down-regulation of 5-HT2AR in HCVcc-infected Huh7.5.1 cells.
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