The resulting hemolysis is entirely complement-dependent and the temperature optimum for complement activation is at 37°C [ 78, 79].
Given that hemolysis in CAD is entirely complement-dependent, studies of complement inhibition would be relevant in CAD.
Complement activation plays a definitive but limited role in warm-antibody AIHA (w-AIHA), whereas primary cold agglutinin disease (CAD), secondary cold agglutinin syndrome (CAS), and paroxysmal cold hemoglobinuria (PCH) are entirely complement-dependent disorders.
Furthermore, though paroxysmal nocturnal hemoglobinuria (PNH) is not an autoimmune disorder, the entirely complement-dependent pathogenesis and the success of therapeutic complement inhibition in this disease make it possible to learn lessons from PNH that might prove useful in treating AIHA [ 12].
The identified SNPs and small indels were listed in Additional file 4. Natural antisense transcripts (NATs) are endogenous RNA sequences partially or entirely complemented to other transcripts and cis-NAT pairs are two transcripts from the same genomic locus but on opposite strands [ 49].
The 82nd, under Major General Matthew Ridgway, performed admirably, but soon left the corps, and once in Brittany the corps would have an entirely different complement of divisions.
Despite the loss of interaction with E90 and employing an almost entirely new complement of QacR residues, this new binding site in the QacR(E90Q -Et complE90Q -Etited binding affinity and inducomplexapabilitiexhibited essentially the same as wt QacR (Tabindingaffinity
The peak 2 population of histone H3 contained an entirely different complement of species and, based solely on the masses observed, there is no obvious explanation of why this pool of molecules has a distinct LC elution profile (Fig. 5g).
In this new era, computers may entirely replace the instruments that they had previously only complemented.
All complements of Bloomingdale's.
Political and military preparations have not gone hand-in-hand, but have entirely failed to complement each other.
