Infectious prion particles are composed largely, if not entirely, of an abnormal isoform of the prion protein, which is encoded by a chromosomal gene.
It is entirely possible that these abnormal gene polymorphisms could be very old and have never caused a problem until there was sufficient changes in the environment (the thrifty gene hypothesis: gene – environmental interaction).
The agent remains entirely intravascular and with it, any abnormal vascular supply will demonstrate different enhancement.
More important, however, the four study groups (entirely composed of women with an abnormal GCT) showed marked metabolic differences on the subsequent OGTT.
These results may reflect that abnormal mineral metabolism is not entirely responsible for vascular calcification in CKD and suggest that factors other than the serum levels of calcium and phosphorus play an important role in the development of vascular calcification.
Null Hmx2 mutants develop abnormal vestibular apparatus; with inner ears entirely lacking semicircular canals, with fused utricles and saccules and a significant loss of vestibular sensory epithelium [ 54].
This continuum is not necessarily linear, and specific components can confer entirely different risk despite being classified as "normal" or "abnormal" when assessed strictly by using a single threshold value.
The second, in contrast, is highly abnormal as far as OB interneurons go but entirely 'normal' with respect to the rest of the brain, because these cells have a clearly defined axon and are generated exclusively in early embryonic development.
In line with this notion, several studies suggest that episodic memory impairment in schizophrenia is largely due to abnormal encoding of episodes, even though retrieval may not be entirely spared [29] [35].
The reason for this phenomenon is not entirely clear and it is possible that some FGD tend to share similar patho-physiological mechanisms such as abnormal visceral sensitivity, abnormal intestinal motility and malfunctioning brain-gut communications.
