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Goldstein considered the entire range of effect sizes as we do.
However, it should be noted that we are considering the entire range of effect sizes rather than the observed range, which is a bit trickier.
Power was, as expected, consistently lower across the entire range of effect sizes and allele frequencies compared to a sample size of 20,000 (Table S2) and 80,000 (Table S3).
However, the problem addressed in this study is not exactly the same as in Park et al. We are considering the entire range of effect sizes while in Park et al the range of effect sizes is limited to those observed for known susceptibility variants.
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The dose response data for the single agents, pooled from all studies, were used to compute predicted dose-additive combination effects covering the entire range of effects.
The dose ranges were chosen with the aim to cover the entire range of effects from no effect up to maximum effects, as determined by measurement of AGD and NR.
It is fair mentioning that there is another potential misleading factor in the comparison between mutations in TEV 5' UTR and in the ORF: mutations in Carrasco et al. [ 19] were selected at random, while mutations here were selected to cover the entire range of effects on the in silico secondary structure.
Because the entire range of observed effects is not capable of simple quantitative definition, the strength of the shaking is commonly estimated by reference to intensity scales that describe the effects in qualitative terms.
Doing so requires rigorous peer-reviewed data and analyses across the entire range of direct and indirect effects.
In the group with no previous admission, there is no outward expression of this underlying dimension; furthermore, individuals within this group would also be expected to exhibit the entire range of severity, with the overall effect observed therefore representing an averaging process.
Moreover, we widen the scope by considering the entire range of putative modifications with relative effects varying from 0% to 100%, and we furthermore introduce survival costs incurred by mutant individuals in order to assess the effect of such costs on the fate of the mutation.
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